Affiliate Faculty (617) 253-6421 sharppa@mit.edu. This work provided one of the first indications of the startling phenomenon of “discontinuous genes” in mammalian cells. AKA Richard John Roberts. Born in rural Kentucky and raised in the same house where his mother grew up, Sharp was firmly rooted in the small community where he spent his youth. The functions of condensates are also being investigated in relationship to RNA splicing, chromatin modifications and transcription.". We are using computational methods to identify, by comparison of genomic sequences from multiple organisms, intron and exon sequences which are important for accurate splicing and for control of alternative RNA splicing. Gender: Male Religion: Agnostic Race or Ethnicity: White Sexual orientation: Straight Oc. His landmark work in 1977 provided the first indications of “discontinuous genes” in mammalian cells. To explore the regulatory functions of alternative splicing in mammalian differentiation, in collabora­tion with the Phillip Sharp lab we are using splicing-sensitive microarrays to analyze changes in the expression of alternative mRNA isoforms following activation of primary T-cells. Sharp Rees-Stealy Sorrento Mesa Laboratory Sharp Rees-Stealy Medical Group. Photo courtesy / Philip Sharp laboratory Previous image Next image Andrew Z. More recently, he was founding director of the McGovern Institute, a position he held from 2000 to 2004. For his discovery of "split genes", molecular biologist Richard J. Roberts won the Nobel Prize for Medicine in 1993, sharing the honor with Phillip A. In a study appearing in Nature, researchers from the lab of KI Director and David H. Koch Professor of Biology Tyler Jacks, together with Phillip Sharp’s and Daniel Anderson’s labs, have shown that they can generate liver tumors in adult mice by using CRISPR, a gene-editing tool, to disrupt tumor suppressor genes p53 and pten. Cancer Cell 21, 848-55 (2012). For further details about the Sharp Lab, click here. For example, both require P-TEFb activity for elongation beyond about 50 nts. Most promoters and enhancers in mammalian cells are transcribed divergently with RNA polymerases initiating in both directions. Sharp is Institute Professor at the Massachusetts Institute of Technology, the highest academic rank at the Institute. RNA interference (RNAi) has dramatically expanded the possibilities for genotype/phenotype analysis in cell biology and for therapeutic intervention. Divergent transcription generates thousands of short non-coding RNAs. To schedule, sign in to FollowMyHealth or call 619-446-1543. NIHMSID: 94606, Sandberg R, Neilson JR, Sarma A, Sharp PA, Burge, C. Widespread evasion of posttranscriptional regulation associated with proliferation. These divergent nascent RNAs are thought to facilitate the formation of a condensate promoting a burst of transcription. 500 Main Street, Building 76 Phillip Sharp’s landmark achievement came in 1977, when he and his colleague Richard Roberts discovered RNA splicing. The General Data Protection Regulation (GDPR) governs the processing of personal information gathered from individuals while they are in the European Union (EU) and parts of the EEA (European Economic Area, which currently includes Iceland, Lichtenstein and Norway). Sharp Biographical A sense of place was and remains an important part of my life. Dr. Sharp has authored over 400 papers. Splitting their time between lab and clinic, Whitehead physician-scientists bring research and reassurance to patients. Dr. Brown's research laboratory focuses on elucidating the epigenetic factors underlying the action of steroid hormones. The discovery fundamentally changed scientists' understanding of gene structure and earned Dr. Sharp the 1993 Nobel Prize in Physiology or Medicine. Among his many awards are the Gairdner Foundation International Award, the Lasker Basic Medical Research Award and the National Medal of Science. We have recently reported that divergent transcription is common of promoter sites for genes in embryonic stem cells (see Figure). If you can spare a few minutes, please help us improve our website by completing this survey. , Chakraborty AK, Sharp PA a B.A made within molecular biology of gene expression relevant Cancer..., I am doing the worst Professor I have ever had phillip Sharp a... Elucidating the epigenetic factors underlying the action of steroid hormones ) 253-4398 sodini mtl.mit.edu. 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