View abstract. 2003;116(1):15-19. A., Imdad, A., Ramakrishnan, U., and Martorell, R. Is it time to replace iron folate supplements in pregnancy with multiple micronutrients? Arch.Dis.Child 1979;54(9):699-702. View abstract. Association between folate intake and risk of head and neck squamous cell carcinoma: An overall and dose-response PRISMA meta-analysis. View abstract. Lowering blood homocysteine with folic acid-based supplements: meta-analysis of randomised trials. Thambyrajah J, Landray MJ, McGlynn FJ, et al. View abstract. View abstract. J Renal Nutr 2001;11:67-72. View abstract. Ann.Nutr.Metab 2011;59(1):38-40. Dierkes J, Domrose U, Bosselmann P, et al. Hoch, A. Power shortage: clinical trials testing the "homocysteine hypothesis" against a background of folic acid-fortified cereal grain flour. Ann Intern Med 2007;146:1-9. View abstract. Coull, B. M., Malinow, M. R., Beamer, N., Sexton, G., Nordt, F., and de, Garmo P. Elevated plasma homocyst(e)ine concentration as a possible independent risk factor for stroke. Br J Nutr 2006;96(1):182-190. 2016;98(1):18-27. Manns B, Hyndman E, Burgess E, et al. J Neurol Sci 1997;145:109-12. Ntaios, G., Savopoulos, C., Karamitsos, D., Economou, I., Destanis, E., Chryssogonidis, I., Pidonia, I., Zebekakis, P., Polatides, C., Sion, M., Grekas, D., and Hatzitolios, A. Homocysteine and cardiovascular disease: current evidence and future prospects. A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. View abstract. 2013 23;381(9871):1029-36. Erlichman, C., Fine, S., Wong, A., and Elhakim, T. A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. Measurement of carotid plaque and effect of vitamin therapy for total homocysteine. Nat.Clin Pract.Nephrol. Am J Obstet.Gynecol. Am.J Clin.Nutr 2005;82(4):806-812. View abstract. It also has been seen to reduce nausea from methotrexate. Loscalzo J. Folate and nitrate-induced endothelial dysfunction. 1998. Saposnik, G. Meta analysis suggests that folic acid supplementation does not reduce risk of stroke, but there may be some benefit when given in combination with vitamins B6 and B12 and in primary prevention. Am.J.Epidemiol. View abstract. Areekul, S., Subcharoen, A., Cheeramakara, C., Srisukawat, K., and Limsuwan, S. Studies on the effect of folic acid supplement on folate and vitamin B12 status in children. Williams, L. J., Mai, C. T., Edmonds, L. D., Shaw, G. M., Kirby, R. S., Hobbs, C. A., Sever, L. E., Miller, L. A., Meaney, F. J., and Levitt, M. Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States. Sydow, K., Schwedhelm, E., Arakawa, N., Bode-Boger, S. M., Tsikas, D., Hornig, B., Frolich, J. C., and Boger, R. H. ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins. Gastroenterology. Effects of folic acid treatment on homocysteine levels and vascular disease in hemodialysis patients. A type of throat cancer (pharyngeal cancer). View abstract. 5'-methyltetrahydrofolate, 5'-methyltetrahydrofolic acid, 5'-MTHF, Acide Folique, Acide Ptéroylglutamique, Acide Ptéroylmonoglutamique, Acido Folico, B Complex Vitamin, Complexe de Vitamines B, Complexe Vitaminique B, Dihydrofolate, Dihydrofolic Acid, Folacin, Folacine, Folate, Folinic Acid, L-methylfolate, Methylfolate, Méthylfolate, Methylfolic Acid, Pteroylglutamic Acid, Pteroylmonoglutamic Acid, Pteroylpolyglutamate, Tetrahydrofolate, Tétrahydrofolate, Vitamin B9, Vitamine B9. Some evidence suggests that taking folic acid does not help medications for chest pain (nitrates) work longer. Effect of Folic Acid Supplementation on Seizure Control in Epileptic Children Receiving Long Term Antiepileptic Therapy. View abstract. Folic acid supplements are available in tablet or liquid forms. Cardiovasc.Ther. Birth Defects Res A Clin Mol.Teratol. Kim, Y. I., Baik, H. W., Fawaz, K., Knox, T., Lee, Y. M., Norton, R., Libby, E., and Mason, J. 2012;28(2):221-229. Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. View abstract. 2014;167:306-11. Stevens VL, McCullough ML, Sun J, Jacobs EJ, Campbell PT, Gapstur SM. Effect of folic acid combined with docosahexaenoic acid intervention on mild cognitive impairment in elderly: a randomized double-blind, placebo-controlled trial. View abstract. View abstract. In a study published in the journal Fertility and Sterility, men were given 5 mg of folic acid and 66 mg of zinc a day for 26 weeks. J Clin Lipidol. Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Meyskens, F. L., Jr., Omenn, G. S., Valanis, B., and Williams, J. H., Jr. Slattery ML, Schaffer D, Edwards SL, et al. The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. McNeill, G., Avenell, A., Campbell, M. K., Cook, J. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis (Cochrane Review). Tseng M, Murray SC, Kupper LL, Sandler RS. Imasa, M. S., Gomez, N. T., and Nevado, J. View abstract. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Meijer, W. M., Werler, M. M., Louik, C., Hernandez-Diaz, S., de Jong-van den Berg LT, and Mitchell, A. 2009;85(4):269-273. Clarke, R., Bennett, D. A., Parish, S., Verhoef, P., Dotsch-Klerk, M., Lathrop, M., Xu, P., Nordestgaard, B. G., Holm, H., Hopewell, J. C., Saleheen, D., Tanaka, T., Anand, S. S., Chambers, J. C., Kleber, M. E., Ouwehand, W. H., Yamada, Y., Elbers, C., Peters, B., Stewart, A. F., Reilly, M. M., Thorand, B., Yusuf, S., Engert, J. C., Assimes, T. L., Kooner, J., Danesh, J., Watkins, H., Samani, N. J., Collins, R., and Peto, R. Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. 1993;80(4):499-501. View abstract. Effect of homocysteine-lowering therapy on vascular endothelial function and exercise performance in coronary patients with hyperhomocysteinaemia. Food Nutr Bull 2009;30(4 Suppl):S547-S555. Psychol.Med 1971;1(2):166-171. Maruti, S. S., Ulrich, C. M., and White, E. Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk. JAMA Pediatr. Arch Intern Med 2004;164:2335-42. Am.J Med.Genet.A 4-1-2008;146(7):803-812. 2018;362:k3478. Lewerin, C., Matousek, M., Steen, G., Johansson, B., Steen, B., and Nilsson-Ehle, H. Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study. Folic acid is the synthetic version of the water-soluble vitamin folate, a B-vitamin (B9). 1997;90(8):519-524. Goh, Y. I., Bollano, E., Einarson, T. R., and Koren, G. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Clin Gastroenterol 2008;42 Suppl 3 Pt 2:S179-S184. Acta Obstet.Gynecol.Scand 1996;75(8):725-729. Folic acid, N-[ p [[(2-amino-4-hydroxy-6-pteridinyl)methyl]-amino]benzoyl]-L-glutamic acid, is a B complex vitamin containing a pteridine moiety linked by a methylene bridge to para-aminobenzoic acid, which is joined by a peptide linkage to glutamic acid.Conjugates of folic acid … Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes. A randomized controlled trial to examine the effect of 2-year vitamin B12 and folic acid supplementation on physical performance, strength, and falling: additional findings from the B-PROOF study. Bostom AG, Garber C. Endpoints for homocysteine-lowering trials. View abstract. Mora JO, de Navarro L, Clement J, Wagner M, de Paredes B, and Herrera MG. Wactawski-Wende J, Kotchen JM, Anderson GL. Reynolds EH. J Geriatr.Psychiatry Neurol. Folic acid is needed to prevent red blood cell abnormalities and anemia. View abstract. View abstract. Chen P, Li C, Li X, Li J, Chu R, Wang H. Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis. View abstract. Br J Dermatol. Sandler, R. S., Halabi, S., Baron, J. View abstract. View abstract. Lewis DP, Van Dyke DC, Willhite LA, et al. Chin Med.J.(Engl.) Zhang, S. M., Willett, W. C., Selhub, J., Hunter, D. J., Giovannucci, E. L., Holmes, M. D., Colditz, G. A., and Hankinson, S. E. Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. Wong WY, Merkus HM, Thomas CM, et al. Kirke, P. N., Daly, L. E., and Elwood, J. H. A randomised trial of low dose folic acid to prevent neural tube defects. Dietary folate equivalents: interpretation and application. View abstract. Cochrane Database Syst Rev 2003;(2):CD003390.. View abstract. Proc.Nutr.Soc. J Am Med Assoc 1980;244:633-4. View abstract. View abstract. Folate is important because it acts … Am.J Clin.Nutr 2005;82(4):717-718. Cancer Epidemiol. Roswall N, Olsen A, Christensen J, et al. Melse-Boonstra, A., Lievers, K. J., Blom, H. J., and Verhoef, P. Bioavailability of polyglutamyl folic acid relative to that of monoglutamyl folic acid in subjects with different genotypes of the glutamate carboxypeptidase II gene. Multivitamin supplementation in oral contraceptive users. View abstract. Goh, Y. I., Bollano, E., Einarson, T. R., and Koren, G. Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis. Yakoob, M. Y. and Bhutta, Z. 1998;26(1):1-13. Public Health Nutr 2000;3:125-50.. View abstract. Folic acid is a synthetic, water-soluble vitamin used in supplements and fortified foods. 2003;5(4):315-322. Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia. Free shipping A., Sherwood, R. A., Asonganyi, B., Swift, C. G., Thomas, S., and Jackson, S. H. Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes. Mangoni, A. MacLennan, R., Macrae, F., Bain, C., Battistutta, D., Chapuis, P., Gratten, H., Lambert, J., Newland, R. C., Ngu, M., Russell, A., and . View abstract. Dietary folate and depressive symptoms are associated in middle-aged Finnish men. View abstract. Taking folic acid every other day might lower levels of homocysteine in the blood caused by the drug fenofibrate. Am Fam Physician 1986;33:165-74. Bedford Laboratories. B., Vermaak, W. J., van der Merwe, A., Becker, P. J., Delport, R., and Potgieter, H. C. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. Sickle-cell disease. View abstract. Taking folic acid during pregnancy does not decrease the risk of having a premature baby. Prevention of anemia in premature infants?]. Carpenter NJ, Barber DH, Jones M, Lindley W, and Carr C. Controlled six-month study of oral folic acid therapy in boys with fragile X-linked mental retardation. A controlled trial of homocysteine lowering and cognitive performance. Do low doses of folic acid result in maximum lowering of homocysteine? J Am Coll Cardiol 2000;36:758-65. Kuo, H. K., Sorond, F. A., Chen, J. H., Hashmi, A., Milberg, W. P., and Lipsitz, L. A. J Epidemiol.Community Health 2007;61(7):631-637. 2015;33(9):1897-906. View abstract. Supplemental vitamins and minerals for CVD prevention and treatment. 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Taking a specific nutritional supplement with added folic acid and possibly vitamin B12 does not seem to prevent diarrhea in children at risk of malnutrition. Lancet 4-25-1970;1(7652):867-868. 2-16-2010;50(4):235-244. Am.J.Clin Nutr. Folic Acid … Badovinac, R. L., Werler, M. M., Williams, P. L., Kelsey, K. T., and Hayes, C. Folic acid-containing supplement consumption during pregnancy and risk for oral clefts: a meta-analysis. Acta Biomed Ateneo Parmense 1989;60:245-8. Am.J.Clin Nutr. Eur J Gastroenterol Hepatol. Lajous, M., Romieu, I., Sabia, S., Boutron-Ruault, M. C., and Clavel-Chapelon, F. Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women. View abstract. 2011;93(5):941-949. Arterioscler Thromb Vasc Biol 1999;19:2918-21. US Preventive Services Task Force, Bibbins-Domingo K, Grossman DC, et al. View abstract. Taking folic acid might help slow kidney function decline in people with CKD. Lassi ZS, Salam RA, Haider BA, Bhutta ZA. III. 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Frunutta Folic Acid 1000 mcg, Under The Tongue Instant Dissolve Tablets, 3 Month Supply, Proudly Made in USA 4.8 out of 5 stars 221 $14.99$14.99 ($0.15/Count) Save 5% more with Subscribe & Save Behzadi, A. H., Omrani, Z., Chalian, M., Asadi, S., and Ghadiri, M. Folic acid efficacy as an alternative drug added to sodium valproate in the treatment of acute phase of mania in bipolar disorder: a double-blind randomized controlled trial. Milunsky, A., Jick, H., Jick, S. S., Bruell, C. L., MacLaughlin, D. S., Rothman, K. J., and Willett, W. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. View abstract. Drugs and Aging 2000;16:251-60.. View abstract. Arch.Gerontol.Geriatr. Arch.Dis.Child 1981;56(12):911-918. Public Health Nutr 1998;1(3):147-156. Montagnani, F., Chiriatti, A., Turrisi, G., Francini, G., and Fiorentini, G. A systematic review of FOLFOXIRI chemotherapy for the first-line treatment of metastatic colorectal cancer: improved efficacy at the cost of increased toxicity. View abstract. Sanjoaquin, M. A., Allen, N., Couto, E., Roddam, A. W., and Key, T. J. Folate intake and colorectal cancer risk: a meta-analytical approach. 2003;12(2):161-164. Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials. 2. There are some important factors to consider before deciding on a folic acid dosage. Lancet 4-30-2011;377(9776):1523-1538. Zhang B, Shang S, Li S, et al. Mark, S. D., Wang, W., Fraumeni, J. F., Jr., Li, J. Y., Taylor, P. R., Wang, G. Q., Guo, W., Dawsey, S. M., Li, B., and Blot, W. J. Graham I. Interactions between homocysteinaemia and conventional risk factors in vascular disease. View abstract. 2014;126(2):101-5. Folic acid helps your body produce and maintain new cells, and also helps prevent changes to DNA that may lead to cancer. MacMahon, M., Kirkpatrick, C., Cummings, C. E., Clayton, A., Robinson, P. J., Tomiak, R. H., Liu, M., Kush, D., and Tobert, J. Dement.Geriatr Cogn Disord 2002;13(4):225-234. Do not take extra medicine to make up the missed dose. Maxwell, C. J., Hogan, D. B., and Ebly, E. M. Serum folate levels and subsequent adverse cerebrovascular outcomes in elderly persons. View abstract. View abstract. 1. View abstract. View abstract. But this has not been confirmed in good quality studies. Cochrane.Database.Syst.Rev. McKeown-Eyssen G, Holloway C, Jazmaji V, et al. View abstract. View abstract. Am J Med Genet. 2009;19(4):226-230. In most people, folic acid does not help with these symptoms. View abstract. Methotrexate and trimethoprim are specific anti-folates and the folate deficiency caused by their … Lam, V. W., Spiro, C., Laurence, J. M., Johnston, E., Hollands, M. J., Pleass, H. C., and Richardson, A. J. Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study. JAMA 7-6-2005;294(1):47-55. View abstract. 2017;35(6):1302-1309. Eur.J.Cancer 2004;40(8):1250-1254. Winkels, R. M., Brouwer, I. 2006;15(3):443-448. Righetti, M., Serbelloni, P., Milani, S., and Ferrario, G. Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients. Some research shows that folic acid might help prevent or treat Alzheimer disease. J Clin Periodontol. Nutr Metab Cardiovasc.Dis. 1994;17(1):159-162. 2020:S0261-5614(20)30398-8. If you’re planning to have a baby, it’s important that you take folic acid tablets for two to three months before … Shiraishi M, Haruna M, Matsuzaki M, Ota E, Murayama R, Murashima S. Association between the serum folate levels and tea consumption during pregnancy. Nutr Rev 2008;66(6):349-353. Effect of folic acid and zinc supplementation in men on semen quality and live birth among couples undergoing infertility treatment: a randomized clinical trial. Non-cancerous growths in the large intestine and rectum (colorectal adenoma). Design of clinical trials to test the homocysteine hypothesis of vascular disease. Cochrane.Database.Syst.Rev 2006;3:CD004736. Am J Alzheimers.Dis.Other Demen. Eur J Clin Nutr 2000;54:424-8. Effect of folic acid treatment on endothelium-dependent vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects. Bronstrup A. The following doses have been studied in scientific research: ADULTS BY MOUTH: Did you or will you purchase this product in-store or online? View abstract. Settlement Reached for Health Claim Relating B Vitamins and Vascular Disease. 2001;94(8):435-444. 2010;64(2):208-215. Tchernia, G., Blot, I., Rey, A., Kaltwasser, J. P., Zittoun, J., and Papiernik, E. 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J., Probstfield, J., Fodor, G., Held, C., and Genest, J., Jr. Homocysteine lowering with folic acid and B vitamins in vascular disease. Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Diabetes Care 2000;23:1816-22. Am.J.Epidemiol. JAMA 2009;302:2119-26. Lewis DP, Van Dyke DC, Stumbo PJ, Berg MJ. View abstract. Durga, J., Bots, M. L., Schouten, E. G., Grobbee, D. E., Kok, F. J., and Verhoef, P. Effect of 3 y of folic acid supplementation on the progression of carotid intima-media thickness and carotid arterial stiffness in older adults. J.Natl.Cancer Inst. Can.J Cardiol 2010;26(9):461-465. Intake of selected micronutrients and risk of colorectal cancer. View abstract. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. View abstract. Clarke, R., Halsey, J., Bennett, D., and Lewington, S. 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View abstract. 2012;34(4):459-467. McKay DL, Perrone G, Rasmussen H, et al. View abstract. Smithells, R. W., Nevin, N. C., Seller, M. J., Sheppard, S., Harris, R., Read, A. P., Fielding, D. W., Walker, S., Schorah, C. J., and Wild, J. Pediatrics 1979;64(3):333-335. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. 2011;30(5):285-294. Biochem Pharmacol 1992;44:1839-42. 2007;79(1):8-15. View abstract. View abstract. Galeone C, Edefonti V, Parpinel M, Leoncini E, Matsuo K, Talamini R, Olshan AF, Zevallos JP, Winn DM, Jayaprakash V, Moysich K, Zhang ZF, Morgenstern H, Levi F, Bosetti C, Kelsey K, McClean M, Schantz S, Yu GP, Boffetta P, Lee YC, Hashibe M, La Vecchia C, Boccia S. Folate intake and the risk of oral cavity and pharyngeal cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology Consortium. A. Information from this source is evidence-based and objective, and without commercial influence. Debreceni, B. and Debreceni, L. Why do homocysteine-lowering B vitamin and antioxidant E vitamin supplementations appear to be ineffective in the prevention of cardiovascular diseases? Suitor CW, Bailey LB. Sood, S. K., Ramachandran, K., Mathur, M., Gupta, K., Ramalingaswamy, V., Swarnabai, C., Ponniah, J., Mathan, V. I., and Baker, S. J. W.H.O. Am J Clin Nutr 2000;72:1156-63.. View abstract. Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas. View abstract. Hill MJ. J Am Diet Assoc 2004;104(12):1793-1799. Int J Clin Oncol. Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study. View abstract. View abstract. Ophthalmology 2012;119(12):2493-2499. Lancet Neurol. Arterioscler.Thromb.Vasc.Biol. Cook, N. R., Lee, I. M., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., and Buring, J. E. 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Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease. Folate for oral contraceptive users may reduce cervical cancer risk. 2006;76(10):714-717. View abstract. Lin RJ, Krall R, Westerberg BD, et al. Cole, B. F., Baron, J. View abstract. A., and Uauy, Dagach R. [Effect of folate and related nutrients on cognitive function in older people; systematic review]. Lewis, S. J., Harbord, R. M., Harris, R., and Smith, G. D. Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk. Logan EC, Williamson LM, Ryrie DR. Sulphasalazine associated pancytopenia may be caused by acute folate deficiency. Depression and tetrahydrobiopterin: the folate connection. Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia. (Accessed 18 March 10). Methotrexate (MTX, Rheumatrex) works by decreasing the effects of folic acid in the body's cells. Acta Obstet.Gynecol.Scand. A randomized double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease. View abstract. J Obstet.Gynaecol.Br Commonw. 2012;45(16-17):1286-1294. View abstract. J.Natl.Cancer Inst. Calorie and protein intake of pregnant women acid lowers homocysteine levels intake to lower risk of stroke people! Sulphasalazine associated pancytopenia may be caused by the drug lometrexol copyrighted material is provided by natural medicines Comprehensive Database Version.©... M. S., Lauritzen, L. Chemoprevention of colorectal polyps and their relatives stroke among with! Uauy, Dagach R. [ folic acid antenatal supplements on maternal haematology and fetal growth probiotic strains prevent! Adenoma ) 665 mcg DFE ) tablets, 250 count ( 5736 ):644-648 ; systematic and... Methotrexate, so it must be replenished through supplementation, riboflavin, thiamin, and Yaol S. effect. ):2175-2178 Solyom, L. 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